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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1308880
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tbcel
Name: tubulin folding cofactor E-like
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionISORGD:15507846480464CTDTetrachlorodibenzodioxin affects the expression of TBCEL mRNA

PMID:18343893, PMID:21570461, PMID:26377647
increases expressionISORGD:15507846480464CTDTetrachlorodibenzodioxin results in increased expression of TBCEL mRNA

PMID:23994337
multiple interactionsISORGD:15507846480464CTD[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of TBCEL mRNA, [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression of TBCEL mRNA

PMID:16214954, PMID:25975270
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.