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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1307914
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ptdss2
Name: phosphatidylserine synthase 2
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ptdss2decreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of PTDSS2 mRNA

PMID:21215274
Ptdss2affects expressionISORGD:13173856480464CTDTetrachlorodibenzodioxin affects the expression of PTDSS2 mRNA

PMID:21570461
Ptdss2decreases expressionISORGD:13173856480464CTDTetrachlorodibenzodioxin results in decreased expression of PTDSS2 mRNA

PMID:21354282
Ptdss2increases expressionISORGD:13173856480464CTDTetrachlorodibenzodioxin results in increased expression of PTDSS2 mRNA

PMID:19465110
Ptdss2multiple interactionsISORGD:13173856480464CTDTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to PTDSS2 promoter]

PMID:19654925
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.