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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1307594
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slc46a3
Name: solute carrier family 46, member 3
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc46a3affects expressionISOSlc46a3 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of SLC46A3 mRNAPMID:20702594 PMID:26377647
Slc46a3increases expressionISOSlc46a3 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of SLC46A3 mRNAPMID:19770486 PMID:21889950 PMID:25975270 PMID:26290441 PMID:32553695
Slc46a3multiple interactionsISOSlc46a3 (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of SLC46A3 mRNA; [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression of SLC46A3 mRNAPMID:16214954 PMID:25975270
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