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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1307472
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pkp1
Name: plakophilin 1
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pkp1increases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of PKP1 mRNAPMID:33387578
Pkp1affects expressionISOPkp1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of PKP1 mRNAPMID:21570461 PMID:26377647
Pkp1increases expressionISOPKP1 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in increased expression of PKP1 mRNA; Tetrachlorodibenzodioxin results in increased expression of PKP1 proteinPMID:23152189 PMID:37788135
Pkp1increases expressionISOPkp1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of PKP1 mRNAPMID:17035482 PMID:27562557
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