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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1307332
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Srxn1
Name: sulfiredoxin 1
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Srxn1decreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of SRXN1 mRNAPMID:32109520
Srxn1increases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of SRXN1 mRNAPMID:18796159 PMID:27136898
Srxn1affects expressionISOSrxn1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of SRXN1 mRNAPMID:20702594 PMID:21570461 PMID:26377647
Srxn1increases expressionISOSRXN1 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in increased expression of SRXN1 mRNAPMID:20106945 PMID:21632981 PMID:26198647 PMID:26238291
Srxn1increases expressionISOSrxn1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of SRXN1 mRNAPMID:18796159 PMID:21851831 PMID:25975270 PMID:26290441
Srxn1multiple interactionsISOSRXN1 (Homo sapiens)6480464CTD[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in increased expression of SRXN1 mRNAPMID:26159488
Srxn1multiple interactionsISOSrxn1 (Mus musculus)6480464CTD2,4,5,2',4',5'-hexachlorobiphenyl promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of SRXN1 mRNA]; [Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of SRXN1 mRNA; [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SRXN1 mRNA; [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression of SRXN1 mRNA; Tetrachlorodibenzodioxin promotes the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of SRXN1 mRNA]PMID:16214954 PMID:17942748 PMID:21851831 PMID:25975270
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