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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1307313
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Dkk1
Name: dickkopf WNT signaling pathway inhibitor 1
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dkk1decreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of DKK1 mRNAPMID:33387578
Dkk1decreases expressionISODKK1 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in decreased expression of DKK1 mRNAPMID:20106945 PMID:21632981 PMID:26159488 PMID:26238291 PMID:29704546 PMID:31536130 PMID:36370075
Dkk1decreases expressionISODkk1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of DKK1 mRNAPMID:19770486
Dkk1multiple interactionsISODKK1 (Homo sapiens)6480464CTD2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of DKK1 mRNA]PMID:29704546
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