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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1307153
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Chac1
Name: ChaC glutathione-specific gamma-glutamylcyclotransferase 1
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Chac1affects expressionEXP 6480464CTDTetrachlorodibenzodioxin affects the expression of CHAC1 mRNAPMID:22298810
Chac1increases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of CHAC1 mRNAPMID:21215274 PMID:32109520 PMID:33387578
Chac1affects expressionISOChac1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of CHAC1 mRNAPMID:21570461
Chac1increases expressionISOChac1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of CHAC1 mRNAPMID:19933214
Chac1multiple interactionsISOChac1 (Mus musculus)6480464CTD[TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in decreased expression of CHAC1 mRNAPMID:25975270
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