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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1306757
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rnf125
Name: ring finger protein 125
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Rnf125affects expressionEXP 6480464CTDTetrachlorodibenzodioxin affects the expression of RNF125 mRNAPMID:22298810
Rnf125increases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of RNF125 mRNAPMID:21215274
Rnf125affects expressionISORnf125 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of RNF125 mRNAPMID:16962184 PMID:21570461 PMID:28922406
Rnf125multiple interactionsISORnf125 (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin affects the methylation of RNF125 intron] which results in decreased expression of RNF125 mRNA; [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression of RNF125 mRNAPMID:25975270 PMID:33017471
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