GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Mdm2 | increases degradation | EXP | | 6480464 | CTD | Tetrachlorodibenzodioxin results in increased degradation of MDM2 protein | PMID:15459018 | Mdm2 | increases expression | EXP | | 6480464 | CTD | Tetrachlorodibenzodioxin results in increased expression of MDM2 mRNA | PMID:33387578 | Mdm2 | increases phosphorylation | EXP | | 6480464 | CTD | Tetrachlorodibenzodioxin results in increased phosphorylation of MDM2 protein | PMID:15459018 | Mdm2 | multiple interactions | EXP | | 6480464 | CTD | Tetrachlorodibenzodioxin inhibits the reaction [Etoposide results in increased expression of MDM2 protein]; Tetrachlorodibenzodioxin results in increased expression of and results in increased phosphorylation of and results in increased activity of MDM2 protein | PMID:15459018 | Mdm2 | affects expression | ISO | Mdm2 (Mus musculus) | 6480464 | CTD | Tetrachlorodibenzodioxin affects the expression of MDM2 mRNA | PMID:21570461 | Mdm2 | decreases expression | ISO | MDM2 (Homo sapiens) | 6480464 | CTD | Tetrachlorodibenzodioxin results in decreased expression of MDM2 mRNA | PMID:16039398 | Mdm2 | increases expression | ISO | MDM2 (Homo sapiens) | 6480464 | CTD | Tetrachlorodibenzodioxin results in increased expression of MDM2 mRNA | PMID:19578757 | Mdm2 | increases expression | ISO | Mdm2 (Mus musculus) | 6480464 | CTD | Tetrachlorodibenzodioxin results in increased expression of MDM2 mRNA | PMID:12167310 PMID:21041162 PMID:26290441 | Mdm2 | increases phosphorylation | ISO | MDM2 (Homo sapiens) | 6480464 | CTD | Tetrachlorodibenzodioxin results in increased phosphorylation of MDM2 protein | PMID:19751709 | Mdm2 | multiple interactions | ISO | MDM2 (Homo sapiens) | 6480464 | CTD | alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [Oxygen deficiency results in increased expression of MDM2 mRNA]]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of MDM2 mRNA]; Tetrachlorodibenzodioxin promotes the reaction [Oxygen deficiency results in increased expression of MDM2 mRNA]; Tetrachlorodibenzodioxin promotes the reaction [Oxygen deficiency results in increased expression of MDM2 protein]; Tetrachlorodibenzodioxin results in decreased susceptibility to [1-nitropyrene results in increased expression of MDM2 protein modified form]; Tetrachlorodibenzodioxin results in decreased susceptibility to [1-nitropyrene results in increased expression of MDM2 protein] | PMID:19578757 PMID:22044530 | Mdm2 | multiple interactions | ISO | Mdm2 (Mus musculus) | 6480464 | CTD | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MDM2 mRNA | PMID:17942748 | | ||||||||||||||||||||||
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