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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1305304
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Etnk2
Name: ethanolamine kinase 2
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Etnk2decreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of ETNK2 mRNAPMID:32109520 PMID:33387578
Etnk2affects expressionISOEtnk2 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of ETNK2 mRNAPMID:24680724
Etnk2decreases expressionISOETNK2 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in decreased expression of ETNK2 mRNAPMID:20106945
Etnk2decreases expressionISOEtnk2 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of ETNK2 mRNAPMID:28213091
Etnk2multiple interactionsISOEtnk2 (Mus musculus)6480464CTD[TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in decreased expression of ETNK2 mRNA; Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ETNK2 gene]PMID:25975270 PMID:28213091
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