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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1305256
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Lrrn4
Name: leucine rich repeat neuronal 4
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Lrrn4decreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of LRRN4 mRNAPMID:33387578
Lrrn4affects expressionISOLrrn4 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of LRRN4 mRNAPMID:21570461 PMID:26377647
Lrrn4increases expressionISOLRRN4 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in increased expression of LRRN4 mRNAPMID:20106945 PMID:21632981
Lrrn4multiple interactionsISOLrrn4 (Mus musculus)6480464CTDTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to LRRN4 promoter]PMID:19654925
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