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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10864
Species: Mus musculus
RGD Object: Gene
Symbol: Ldlr
Name: low density lipoprotein receptor
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ldlraffects expressionEXP 6480464CTDTetrachlorodibenzodioxin affects the expression of LDLR mRNAPMID:21570461 PMID:28238261 PMID:28922406 PMID:36222588
Ldlrincreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of LDLR mRNAPMID:22539624 PMID:22977169
Ldlrmultiple interactionsEXP 6480464CTD[Tetrachlorodibenzodioxin affects the methylation of LDLR intron] which results in decreased expression of LDLR mRNA; [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression of LDLR mRNAPMID:25975270 PMID:33017471
Ldlraffects expressionISOLdlr (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin affects the expression of LDLR mRNAPMID:34747641
Ldlrdecreases expressionISOLdlr (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of LDLR mRNAPMID:21215274 PMID:32109520
Ldlrincreases expressionISOLdlr (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin results in increased expression of LDLR mRNAPMID:33387578
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