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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10828
Species: Mus musculus
RGD Object: Gene
Symbol: Jun
Name: jun proto-oncogene
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Junaffects expressionEXP 6480464CTDTetrachlorodibenzodioxin affects the expression of JUN mRNAPMID:21570461 PMID:28922406
Jundecreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of JUN mRNAPMID:21846477 PMID:21889950
Junincreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of JUN mRNA; Tetrachlorodibenzodioxin results in increased expression of JUN proteinPMID:10692565 PMID:11804338 PMID:11879969 PMID:17943652 PMID:18467041 PMID:21496263 PMID:23238561 PMID:24058054 PMID:8917696
Junincreases phosphorylationEXP 6480464CTDTetrachlorodibenzodioxin results in increased phosphorylation of JUN proteinPMID:12213569
Junmultiple interactionsEXP 6480464CTD[Tetrachlorodibenzodioxin co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in decreased expression of JUN mRNA; [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ARNT protein]] which results in increased expression of JUN mRNA; Acetylcysteine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of [FOS protein co-treated with JUN protein]]; AHR protein promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of [FOS protein co-treated with JUN protein]]; CYP1A1 protein promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of [FOS protein co-treated with JUN protein]]; Masoprocol inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of [FOS protein co-treated with JUN protein]]; Tetrachlorodibenzodioxin inhibits the reaction [Lipopolysaccharides results in increased expression of JUN mRNA]; Tetrachlorodibenzodioxin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of JUN protein]; Tetrachlorodibenzodioxin inhibits the reaction [NFE2L2 gene mutant form results in decreased expression of JUN mRNA]; Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to JUN promoter]; Tetrachlorodibenzodioxin promotes the reaction [Lipopolysaccharides results in increased expression of JUN protein]; Tetrachlorodibenzodioxin results in increased activity of [FOS protein co-treated with JUN protein]PMID:10692565 PMID:12051995 PMID:19654925 PMID:20348231 PMID:21167638 PMID:21846477 PMID:21889950 PMID:8917696
Junaffects expressionISOJun (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin affects the expression of JUN mRNAPMID:22298810 PMID:23238561 PMID:34747641
Jundecreases expressionISOJun (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of JUN mRNA; Tetrachlorodibenzodioxin results in decreased expression of JUN proteinPMID:19692669 PMID:8625438
Junincreases activityISOJUN (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in increased activity of JUN proteinPMID:19147701
Junincreases expressionISOJun (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin results in increased expression of JUN mRNAPMID:15897893 PMID:20959002 PMID:33387578 PMID:8625438
Junincreases expressionISOJUN (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in increased expression of JUN mRNAPMID:16697128 PMID:21496263 PMID:21632981 PMID:26238291
Junincreases phosphorylationISOJUN (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in increased phosphorylation of JUN proteinPMID:15019843
Junmultiple interactionsISOJun (Rattus norvegicus)6480464CTD[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of JUN proteinPMID:8625438
Junmultiple interactionsISOJUN (Homo sapiens)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of JUN protein]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of JUN protein]; JUN protein affects the reaction [Tetrachlorodibenzodioxin results in increased activity of MMP9 protein]; JUN protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of MMP9 mRNA]; pyrazolanthrone inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of JUN protein]; Tetrachlorodibenzodioxin promotes the reaction [JUN protein binds to MMP1 promoter]; Tetrachlorodibenzodioxin results in increased phosphorylation of and affects the localization of JUN proteinPMID:15019843 PMID:19371443 PMID:24469321
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