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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10430
Species: Mus musculus
RGD Object: Gene
Symbol: Cyp11b2
Name: cytochrome P450, family 11, subfamily b, polypeptide 2
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp11b2decreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of CYP11B2 mRNAPMID:16962184
Cyp11b2decreases expressionISOCyp11b3 (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of CYP11B2 mRNA; Tetrachlorodibenzodioxin results in decreased expression of CYP11B3 mRNAPMID:33387578
Cyp11b2multiple interactionsISOCYP11B2 (Homo sapiens)6480464CTD[Tetrachlorodibenzodioxin co-treated with 3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with perfluorooctane sulfonic acid co-treated with hexabromocyclododecane co-treated with 2,2',4,4'-tetrabromodiphenyl ether co-treated with tributyltin co-treated with methylmercuric chloride] results in increased expression of CYP11B2 mRNA; [Tetrachlorodibenzodioxin co-treated with 3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with perfluorooctane sulfonic acid] results in increased expression of CYP11B2 mRNAPMID:25765474
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