GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | ICAM1 | increases expression | EXP | | 6480464 | CTD | Nickel results in increased expression of ICAM1; Nickel results in increased expression of ICAM1 mRNA; Nickel results in increased expression of ICAM1 protein | PMID:15715515 PMID:19781536 PMID:23195993 PMID:24768652 PMID:25583101 PMID:7864660 | ICAM1 | multiple interactions | EXP | | 6480464 | CTD | [2-quinoxaline-carboxamide-N-adamantan-1-yl binds to and results in decreased activity of CASR protein] inhibits the reaction [Nickel results in increased expression of ICAM1 mRNA] | PMID:19781536 | ICAM1 | multiple interactions | ISO | Icam1 (Mus musculus) | 6480464 | CTD | [Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of ICAM1 mRNA; TNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of ICAM1 mRNA] | PMID:23503329 | |
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