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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3717
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slc8a1
Name: solute carrier family 8 member A1
Acc ID: CHEBI:28112
Term: nickel atom
Definition: Chemical element (nickel group element atom) with atomic number 28.
Chemical ID: MESH:D009532
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:7310216480464CTDNickel results in decreased expression of SLC8A1 mRNA

PMID:23195993
increases uptakeISORGD:7310216480464CTDSLC8A1 protein results in increased uptake of Nickel

PMID:10329968
multiple interactionsISORGD:7310216480464CTDCalcium inhibits the reaction [SLC8A1 protein results in increased uptake of Nickel], Sodium promotes the reaction [SLC8A1 protein results in increased uptake of Nickel]

PMID:10329968
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.