Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	1345007
Species:	Homo sapiens
RGD Object:	Gene
Symbol:	CYP2E1
Name:	cytochrome P450 family 2 subfamily E member 1

Acc ID:	CHEBI:28097
Term:	chlorobenzene
Definition:	The simplest member of the class of monochlorobenzenes, that is benzene in which a single hydrogen has been substituted by a chlorine.
Chemical ID:	MESH:C031294

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
CYP2E1	increases oxidation	EXP		6480464	CTD	CYP2E1 protein results in increased oxidation of chlorobenzene	PMID:9817075
CYP2E1	multiple interactions	EXP		6480464	CTD	dihydroxyethyldithiocarbamate inhibits the reaction [CYP2E1 protein results in increased metabolism of chlorobenzene]	PMID:9817075
CYP2E1	increases oxidation	ISO	Cyp2e1 (Rattus norvegicus)	6480464	CTD	CYP2E1 protein results in increased oxidation of chlorobenzene	PMID:9817075
CYP2E1	multiple interactions	ISO	Cyp2e1 (Rattus norvegicus)	6480464	CTD	[Benzene results in increased activity of CYP2E1 protein] which results in increased metabolism of chlorobenzene; [Benzene results in increased expression of CYP2E1 protein] which results in increased metabolism of chlorobenzene; dihydroxyethyldithiocarbamate inhibits the reaction [[Benzene results in increased activity of CYP2E1 protein] which results in increased metabolism of chlorobenzene]	PMID:9010585 PMID:9817075

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