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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11275
Species: Mus musculus
RGD Object: Gene
Symbol: Ccl2
Name: C-C motif chemokine ligand 2
Acc ID: CHEBI:28097
Term: chlorobenzene
Definition: The simplest member of the class of monochlorobenzenes, that is benzene in which a single hydrogen has been substituted by a chlorine.
Chemical ID: MESH:C031294
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccl2increases expressionISOCCL2 (Homo sapiens)6480464CTDchlorobenzene results in increased expression of CCL2 proteinPMID:17993253 PMID:18514500 PMID:18645721
Ccl2increases secretionISOCCL2 (Homo sapiens)6480464CTDchlorobenzene results in increased secretion of CCL2 proteinPMID:19800902
Ccl2multiple interactionsISOCCL2 (Homo sapiens)6480464CTD4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [chlorobenzene results in increased expression of CCL2 protein]; bucillamine inhibits the reaction [chlorobenzene results in increased secretion of CCL2 protein]; CCL2 protein promotes the reaction [chlorobenzene results in increased expression of IL13 protein]; SB 203580 inhibits the reaction [chlorobenzene results in increased expression of CCL2 protein]; Tiopronin inhibits the reaction [chlorobenzene results in increased secretion of CCL2 protein]PMID:18514500 PMID:18645721 PMID:19800902
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