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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737102
Species: Homo sapiens
RGD Object: Gene
Symbol: COMT
Name: catechol-O-methyltransferase
Acc ID: CHEBI:28088
Term: genistein
Definition: A 7-hydroxyisoflavone with additional hydroxy groups at positions 5 and 4'. It is a phytoestrogenic isoflavone with antioxidant properties.
Chemical ID: MESH:D019833
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
COMTdecreases activityEXP 6480464CTDGenistein results in decreased activity of COMT proteinPMID:18192686 PMID:18497090
COMTdecreases expressionEXP 6480464CTDGenistein results in decreased expression of COMT mRNAPMID:18192686 PMID:18497090 PMID:30684530
COMTincreases methylationEXP 6480464CTDGenistein results in increased methylation of COMT promoterPMID:30684530
COMTmultiple interactionsEXP 6480464CTD[Genistein results in increased methylation of COMT promoter] which results in decreased expression of COMT mRNA; Fulvestrant inhibits the reaction [Genistein results in decreased expression of COMT mRNA]; Genistein inhibits the reaction [COMT protein results in increased methylation of 4-hydroxyestradiol]; Genistein inhibits the reaction [EP300 protein binds to COMT promoter]; Genistein promotes the reaction [DNMT3B protein binds to COMT promoter]; Genistein promotes the reaction [HDAC1 protein binds to COMT promoter]; Genistein promotes the reaction [MBD2 protein binds to COMT promoter]; sulforaphane inhibits the reaction [Genistein promotes the reaction [HDAC1 protein binds to COMT promoter]]; sulforaphane inhibits the reaction [Genistein promotes the reaction [MBD2 protein binds to COMT promoter]]; sulforaphane inhibits the reaction [Genistein results in decreased expression of COMT mRNA]; sulforaphane inhibits the reaction [Genistein results in increased methylation of COMT promoter]PMID:18192686 PMID:18497090 PMID:30684530
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