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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735516
Species: Homo sapiens
RGD Object: Gene
Symbol: BCL2L1
Name: BCL2 like 1
Acc ID: CHEBI:28088
Term: genistein
Definition: A 7-hydroxyisoflavone with additional hydroxy groups at positions 5 and 4'. It is a phytoestrogenic isoflavone with antioxidant properties.
Chemical ID: MESH:D019833
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
BCL2L1decreases expressionEXP 6480464CTDGenistein results in decreased expression of BCL2L1 proteinPMID:12791511 PMID:18546268 PMID:21078540
BCL2L1multiple interactionsEXP 6480464CTD[Genistein co-treated with arsenic trioxide] results in decreased expression of BCL2L1 protein; Genistein promotes the reaction [arsenic trioxide results in decreased expression of BCL2L1 protein]PMID:18546268 PMID:21078540
BCL2L1decreases expressionISOBcl2l1 (Mus musculus)6480464CTDGenistein results in decreased expression of BCL2L1 mRNA; Genistein results in decreased expression of BCL2L1 proteinPMID:21048042 PMID:21078540
BCL2L1multiple interactionsISOBcl2l1 (Mus musculus)6480464CTD[Genistein co-treated with arsenic trioxide] results in decreased expression of BCL2L1 proteinPMID:21078540
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