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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732873
Species: Homo sapiens
RGD Object: Gene
Symbol: NR0B2
Name: nuclear receptor subfamily 0 group B member 2
Acc ID: CHEBI:28088
Term: genistein
Definition: A 7-hydroxyisoflavone with additional hydroxy groups at positions 5 and 4'. It is a phytoestrogenic isoflavone with antioxidant properties.
Chemical ID: MESH:D019833
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NR0B2decreases expressionISONr0b2 (Mus musculus)6480464CTDGenistein results in decreased expression of NR0B2 mRNAPMID:32186404
NR0B2multiple interactionsISONr0b2 (Rattus norvegicus)6480464CTD[Genistein co-treated with Diethylhexyl Phthalate] results in decreased expression of NR0B2 mRNAPMID:36674726
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