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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732751
Species: Homo sapiens
RGD Object: Gene
Symbol: NR4A1
Name: nuclear receptor subfamily 4 group A member 1
Acc ID: CHEBI:28088
Term: genistein
Definition: A 7-hydroxyisoflavone with additional hydroxy groups at positions 5 and 4'. It is a phytoestrogenic isoflavone with antioxidant properties.
Chemical ID: MESH:D019833
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NR4A1decreases expressionEXP 6480464CTDGenistein results in decreased expression of NR4A1 mRNAPMID:16705744
NR4A1increases expressionEXP 6480464CTDGenistein results in increased expression of NR4A1 mRNAPMID:23019147
NR4A1multiple interactionsEXP 6480464CTD[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of NR4A1 mRNAPMID:27424125
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