GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | VEGFA | decreases expression | EXP | | 6480464 | CTD | Genistein results in decreased expression of VEGF mRNA; Genistein results in decreased expression of VEGFA mRNA; Genistein results in decreased expression of VEGFA protein | PMID:19005980 PMID:21078540 PMID:22228119 | VEGFA | increases secretion | EXP | | 6480464 | CTD | Genistein results in increased secretion of VEGFA protein | PMID:18252963 | VEGFA | multiple interactions | EXP | | 6480464 | CTD | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Genistein results in increased secretion of VEGFA protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Genistein results in increased secretion of VEGFA protein]; [Genistein co-treated with arsenic trioxide] results in decreased expression of VEGFA protein; fulvestrant inhibits the reaction [Genistein results in increased secretion of VEGFA protein]; SB 203580 inhibits the reaction [Genistein results in increased secretion of VEGFA protein]; wortmannin inhibits the reaction [Genistein results in increased secretion of VEGFA protein] | PMID:18252963 PMID:21078540 | VEGFA | decreases expression | ISO | Vegfa (Mus musculus) | 6480464 | CTD | Genistein results in decreased expression of VEGFA mRNA; Genistein results in decreased expression of VEGFA protein | PMID:21048042 PMID:21078540 | VEGFA | increases expression | ISO | Vegfa (Rattus norvegicus) | 6480464 | CTD | Genistein results in increased expression of VEGFA mRNA | PMID:29217487 | VEGFA | increases methylation | ISO | Vegfa (Rattus norvegicus) | 6480464 | CTD | Genistein results in increased methylation of VEGFA gene | PMID:28505145 | VEGFA | multiple interactions | ISO | Vegfa (Mus musculus) | 6480464 | CTD | [Genistein co-treated with arsenic trioxide] results in decreased expression of VEGFA protein; Genistein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of VEGFA mRNA] | PMID:19063610 PMID:21078540 | | ||||||||||||||||||||||
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