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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69123
Species: Homo sapiens
RGD Object: Gene
Symbol: LEP
Name: leptin
Acc ID: CHEBI:28088
Term: genistein
Definition: A 7-hydroxyisoflavone with additional hydroxy groups at positions 5 and 4'. It is a phytoestrogenic isoflavone with antioxidant properties.
Chemical ID: MESH:D019833
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
LEPdecreases response to substanceEXP 6480464CTDGenistein results in decreased susceptibility to LEP proteinPMID:11342529
LEPmultiple interactionsEXP 6480464CTDGenistein inhibits the reaction [LEP protein results in increased chemical synthesis of Reactive Oxygen Species]; Genistein inhibits the reaction [LEP protein results in increased expression of CCL2]PMID:11342529
LEPdecreases expressionISOLep (Mus musculus)6480464CTDGenistein results in decreased expression of LEP mRNA; Genistein results in decreased expression of LEP proteinPMID:18359623
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