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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68384
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccnd1
Name: cyclin D1
Acc ID: CHEBI:28088
Term: genistein
Definition: 7-Hydroxyisoflavone with additional hydroxy groups at positions 5 and 4'. It is a phytoestrogenic isoflavone with antioxidant properties.
Chemical ID: MESH:D019833
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:685566480464CTDGenistein results in decreased expression of CCND1 mRNA, Genistein results in decreased expression of CCND1 protein

PMID:15955619, PMID:21078540
decreases expressionISORGD:685576480464CTDGenistein results in decreased expression of CCND1 mRNA, Genistein results in decreased expression of CCND1 protein

PMID:21048042, PMID:21078540
increases expressionISORGD:685566480464CTDGenistein results in increased expression of CCND1 mRNA, Genistein results in increased expression of CCND1 protein

PMID:15829497, PMID:17051425, PMID:17266178, PMID:19800779, PMID:23524099, PMID:26865669
multiple interactionsISORGD:685566480464CTD[Calcitriol co-treated with Genistein] results in decreased expression of CCND1 mRNA, [Genistein co-treated with arsenic trioxide] results in decreased expression of CCND1 protein, Genistein inhibits the reaction [bisphenol A results in increased expression of CCND1 protein], Genistein inhibits the reaction [bisphenol A results in increased expression of CCND1], Genistein inhibits the reaction [Estradiol results in increased expression of CCND1 protein], Genistein inhibits the reaction [Estradiol results in increased expression of CCND1], lycopene inhibits the reaction [Genistein results in increased expression of CCND1 protein]

PMID:15955619, PMID:17051425, PMID:21078540, PMID:23229410, PMID:23933164
multiple interactionsISORGD:685576480464CTD[Genistein co-treated with arsenic trioxide] results in decreased expression of CCND1 protein

PMID:21078540
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.