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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61995
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pten
Name: phosphatase and tensin homolog
Acc ID: CHEBI:28088
Term: genistein
Definition: A 7-hydroxyisoflavone with additional hydroxy groups at positions 5 and 4'. It is a phytoestrogenic isoflavone with antioxidant properties.
Chemical ID: MESH:D019833
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ptenaffects expressionISOPTEN (Homo sapiens)6480464CTDGenistein affects the expression of PTEN mRNAPMID:26865667
Ptendecreases expressionISOPten (Mus musculus)6480464CTDGenistein results in decreased expression of PTEN mRNAPMID:21048042
Ptenincreases expressionISOPTEN (Homo sapiens)6480464CTDGenistein results in increased expression of PTEN mRNA; Genistein results in increased expression of PTEN proteinPMID:15829497 PMID:20673057
Ptenincreases response to substanceISOPTEN (Homo sapiens)6480464CTDPTEN protein results in increased susceptibility to GenisteinPMID:20673057
Ptenmultiple interactionsISOPTEN (Homo sapiens)6480464CTDdorsomorphin inhibits the reaction [Genistein results in increased expression of PTEN protein]PMID:20673057
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