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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61862
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gria2
Name: glutamate ionotropic receptor AMPA type subunit 2
Acc ID: CHEBI:28088
Term: genistein
Definition: A 7-hydroxyisoflavone with additional hydroxy groups at positions 5 and 4'. It is a phytoestrogenic isoflavone with antioxidant properties.
Chemical ID: MESH:D019833
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gria2decreases expressionEXP 6480464CTDGenistein results in decreased expression of GRIA2 mRNAPMID:22504913
Gria2multiple interactionsEXP 6480464CTDGenistein inhibits the reaction [[Dithionite co-treated with Glucose deficiency] results in decreased expression of GRIA2 protein]PMID:27238724
Gria2increases expressionISOGria2 (Mus musculus)6480464CTDGenistein results in increased expression of GRIA2 mRNAPMID:32186404
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