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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3959
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Vdr
Name: vitamin D receptor
Acc ID: CHEBI:28088
Term: genistein
Definition: A 7-hydroxyisoflavone with additional hydroxy groups at positions 5 and 4'. It is a phytoestrogenic isoflavone with antioxidant properties.
Chemical ID: MESH:D019833
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Vdrincreases expressionISOVDR (Homo sapiens)6480464CTDGenistein results in increased expression of VDR mRNA; Genistein results in increased expression of VDR proteinPMID:12710998 PMID:17088408
Vdrmultiple interactionsISOVDR (Homo sapiens)6480464CTDfulvestrant inhibits the reaction [Genistein results in increased expression of VDR protein]; Genistein promotes the reaction [Calcitriol results in increased expression of VDR mRNA]; Genistein promotes the reaction [Calcitriol results in increased expression of VDR protein]; Genistein promotes the reaction [SP1 protein binds to VDR promoter]; Tamoxifen inhibits the reaction [Genistein results in increased expression of VDR mRNA]; U 0126 inhibits the reaction [Genistein results in increased expression of VDR protein]PMID:12710998 PMID:15955619 PMID:17088408
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