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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3771
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Stat1
Name: signal transducer and activator of transcription 1
Acc ID: CHEBI:28088
Term: genistein
Definition: 7-Hydroxyisoflavone with additional hydroxy groups at positions 5 and 4'. It is a phytoestrogenic isoflavone with antioxidant properties.
Chemical ID: MESH:D019833
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:7321846480464CTDGenistein results in decreased expression of STAT1 protein

PMID:20884965
multiple interactionsISORGD:7321846480464CTDESR2 promotes the reaction [Genistein results in decreased expression of STAT1 protein]

PMID:20884965
multiple interactionsISORGD:7321856480464CTDGenistein inhibits the reaction [Lipopolysaccharides affects the localization of and results in increased activity of STAT1 protein alternative form]

PMID:18274639
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.