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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3439
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ptgs1
Name: prostaglandin-endoperoxide synthase 1
Acc ID: CHEBI:28088
Term: genistein
Definition: A 7-hydroxyisoflavone with additional hydroxy groups at positions 5 and 4'. It is a phytoestrogenic isoflavone with antioxidant properties.
Chemical ID: MESH:D019833
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ptgs1affects expressionISOPTGS1 (Homo sapiens)6480464CTDGenistein affects the expression of PTGS1 mRNAPMID:26865667
Ptgs1decreases expressionISOPtgs1 (Mus musculus)6480464CTDGenistein results in decreased expression of PTGS1 mRNA; Genistein results in decreased expression of PTGS1 proteinPMID:34942354
Ptgs1decreases expressionISOPTGS1 (Homo sapiens)6480464CTDGenistein results in decreased expression of PTGS1 mRNAPMID:20816778
Ptgs1multiple interactionsISOPtgs1 (Mus musculus)6480464CTD[mono-(2-ethylhexyl)phthalate co-treated with Genistein] results in decreased expression of PTGS1 mRNA; [mono-(2-ethylhexyl)phthalate co-treated with Genistein] results in decreased expression of PTGS1 proteinPMID:34942354
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