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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2704
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Glra1
Name: glycine receptor, alpha 1
Acc ID: CHEBI:28088
Term: genistein
Definition: A 7-hydroxyisoflavone with additional hydroxy groups at positions 5 and 4'. It is a phytoestrogenic isoflavone with antioxidant properties.
Chemical ID: MESH:D019833
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Glra1increases expressionEXP 6480464CTDGenistein results in increased expression of GLRA1 mRNAPMID:21782745
Glra1decreases activityISOGLRA1 (Homo sapiens)6480464CTDGenistein results in decreased activity of GLRA1 proteinPMID:20719748
Glra1multiple interactionsISOGLRA1 (Homo sapiens)6480464CTDStrychnine promotes the reaction [Genistein results in decreased activity of GLRA1 protein]PMID:20719748
Glra1multiple interactionsISOGlra1 (Mus musculus)6480464CTDGenistein promotes the reaction [Strychnine results in decreased activity of GLRA1 protein]PMID:20719748
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