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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1346183
Species: Homo sapiens
RGD Object: Gene
Symbol: BID
Name: BH3 interacting domain death agonist
Acc ID: CHEBI:28088
Term: genistein
Definition: A 7-hydroxyisoflavone with additional hydroxy groups at positions 5 and 4'. It is a phytoestrogenic isoflavone with antioxidant properties.
Chemical ID: MESH:D019833
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
BIDdecreases expressionEXP 6480464CTDGenistein results in decreased expression of BID mRNAPMID:22228119
BIDincreases cleavageEXP 6480464CTDGenistein results in increased cleavage of BID proteinPMID:24299158
BIDmultiple interactionsEXP 6480464CTD[Genistein co-treated with TNFSF10 protein] results in increased cleavage of BID protein; Genistein promotes the reaction [arsenic trioxide results in increased cleavage of and results in increased activity of BID protein]; Genistein promotes the reaction [BID protein binds to ESR1 protein]; Genistein results in increased cleavage of and results in increased activity of BID proteinPMID:18546268 PMID:19497411 PMID:27156127
BIDdecreases expressionISOBid (Mus musculus)6480464CTDGenistein results in decreased expression of BID mRNAPMID:30056207
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