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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1332384
Species: Mus musculus
RGD Object: Gene
Symbol: Ren1
Name: renin 1 structural
Acc ID: CHEBI:28088
Term: genistein
Definition: A 7-hydroxyisoflavone with additional hydroxy groups at positions 5 and 4'. It is a phytoestrogenic isoflavone with antioxidant properties.
Chemical ID: MESH:D019833
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ren1multiple interactionsISORen (Rattus norvegicus)6480464CTD[bisphenol A co-treated with Genistein] results in increased methylation of REN gene; Genistein inhibits the reaction [EGF protein results in decreased secretion of REN protein]PMID:28505145 PMID:8491500
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