GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Sirt1 | increases response to substance | ISO | SIRT1 (Homo sapiens) | 6480464 | CTD | SIRT1 protein results in increased susceptibility to Genistein | PMID:28688900 | Sirt1 | multiple interactions | ISO | SIRT1 (Homo sapiens) | 6480464 | CTD | Genistein inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of SIRT1 mRNA]; Genistein inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of SIRT1 protein]; MIR34A mRNA inhibits the reaction [Genistein inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of SIRT1 protein]]; SIRT1 protein promotes the reaction [Genistein inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased acetylation of and affects the localization of FOXO3 protein]] | PMID:28688900 | |
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