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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1308542
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sirt1
Name: sirtuin 1
Acc ID: CHEBI:28088
Term: genistein
Definition: A 7-hydroxyisoflavone with additional hydroxy groups at positions 5 and 4'. It is a phytoestrogenic isoflavone with antioxidant properties.
Chemical ID: MESH:D019833
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sirt1increases response to substanceISOSIRT1 (Homo sapiens)6480464CTDSIRT1 protein results in increased susceptibility to GenisteinPMID:28688900
Sirt1multiple interactionsISOSIRT1 (Homo sapiens)6480464CTDGenistein inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of SIRT1 mRNA]; Genistein inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of SIRT1 protein]; MIR34A mRNA inhibits the reaction [Genistein inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of SIRT1 protein]]; SIRT1 protein promotes the reaction [Genistein inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased acetylation of and affects the localization of FOXO3 protein]]PMID:28688900
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