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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1305369
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nkx3-1
Name: NK3 homeobox 1
Acc ID: CHEBI:28088
Term: genistein
Definition: A 7-hydroxyisoflavone with additional hydroxy groups at positions 5 and 4'. It is a phytoestrogenic isoflavone with antioxidant properties.
Chemical ID: MESH:D019833
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nkx3-1decreases expressionISONKX3-1 (Homo sapiens)6480464CTDGenistein results in decreased expression of NKX3-1 mRNAPMID:15378649 PMID:16865672
Nkx3-1increases expressionISONkx3-1 (Mus musculus)6480464CTDGenistein results in increased expression of NKX3-1 mRNAPMID:21810550
Nkx3-1multiple interactionsISONkx3-1 (Mus musculus)6480464CTDfulvestrant inhibits the reaction [Genistein results in decreased expression of NKX3-1 mRNA]PMID:21810550
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