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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11481
Species: Mus musculus
RGD Object: Gene
Symbol: Vcam1
Name: vascular cell adhesion molecule 1
Acc ID: CHEBI:28088
Term: genistein
Definition: A 7-hydroxyisoflavone with additional hydroxy groups at positions 5 and 4'. It is a phytoestrogenic isoflavone with antioxidant properties.
Chemical ID: MESH:D019833
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Vcam1increases expressionEXP 6480464CTDGenistein results in increased expression of VCAM1 mRNAPMID:32186404
Vcam1multiple interactionsISOVCAM1 (Homo sapiens)6480464CTDESR2 gene polymorphism affects the reaction [[Genistein co-treated with daidzein] affects the expression of VCAM1 protein]; fulvestrant inhibits the reaction [Genistein inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]]; Genistein inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]PMID:12547825 PMID:16332659
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