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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735512
Species: Homo sapiens
RGD Object: Gene
Symbol: MCL1
Name: MCL1 apoptosis regulator, BCL2 family member
Acc ID: CHEBI:28077
Term: rifampicin
Definition: A member of the class of rifamycins that is a a semisynthetic antibiotic derived from Amycolatopsis rifamycinica (previously known as Amycolatopsis mediterranei and Streptomyces mediterranei).
Chemical ID: MESH:D012293
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MCL1multiple interactionsEXP 6480464CTD[Rifampin inhibits the reaction [CYP2C8 protein results in increased susceptibility to Amodiaquine]] which results in decreased expression of MCL1 proteinPMID:31629065
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