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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2458
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a1
Name: cytochrome P450, family 1, subfamily a, polypeptide 1
Acc ID: CHEBI:28077
Term: rifampicin
Definition: A member of the class of rifamycins that is a a semisynthetic antibiotic derived from Amycolatopsis rifamycinica (previously known as Amycolatopsis mediterranei and Streptomyces mediterranei).
Chemical ID: MESH:D012293
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a1increases expressionEXP 6480464CTDRifampin results in increased expression of CYP1A1 mRNAPMID:19118567
Cyp1a1multiple interactionsEXP 6480464CTDRifampin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]PMID:18493746
Cyp1a1increases activityISOCYP1A1 (Homo sapiens)6480464CTDRifampin results in increased activity of CYP1A1 proteinPMID:22733800
Cyp1a1increases expressionISOCYP1A1 (Homo sapiens)6480464CTDRifampin results in increased expression of CYP1A1 mRNA; Rifampin results in increased expression of CYP1A1 proteinPMID:12040753 PMID:19118567 PMID:19409404 PMID:22733800
Cyp1a1multiple interactionsISOCYP1A1 (Homo sapiens)6480464CTD[Methylcholanthrene co-treated with Rifampin co-treated with Phenobarbital] results in increased expression of CYP1A1 mRNA; [Rifampin co-treated with Monocrotophos] results in increased activity of CYP1A1 protein; [Rifampin co-treated with Monocrotophos] results in increased expression of CYP1A1 mRNA; [Rifampin co-treated with Monocrotophos] results in increased expression of CYP1A1 protein; [Tetrachlorodibenzodioxin co-treated with Rifampin] results in increased expression of CYP1A1 mRNA; Rifampin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]PMID:18493746 PMID:22733800 PMID:24999631 PMID:29162470
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