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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1317959
Species: Homo sapiens
RGD Object: Gene
Symbol: AKR1B10
Name: aldo-keto reductase family 1 member B10
Acc ID: CHEBI:28077
Term: rifampicin
Definition: A member of the class of rifamycins that is a a semisynthetic antibiotic derived from Amycolatopsis rifamycinica (previously known as Amycolatopsis mediterranei and Streptomyces mediterranei)
Chemical ID: MESH:D012293
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
AKR1B10increases expressionEXP 6480464CTDRifampin results in increased expression of AKR1B10 mRNA

PMID:29356861
AKR1B10multiple interactionsEXP 6480464CTDpazopanib inhibits the reaction [Rifampin results in increased expression of AKR1B10 mRNA], pimecrolimus inhibits the reaction [Rifampin results in increased expression of AKR1B10 mRNA]

PMID:29356861
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.