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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1317784
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP2C9
Name: cytochrome P450 family 2 subfamily C member 9
Acc ID: CHEBI:28077
Term: rifampicin
Definition: A member of the class of rifamycins that is a a semisynthetic antibiotic derived from Amycolatopsis rifamycinica (previously known as Amycolatopsis mediterranei and Streptomyces mediterranei).
Chemical ID: MESH:D012293
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP2C9affects response to substanceEXP 6480464CTDCYP2C9 alternative form affects the susceptibility to RifampinPMID:36789833
CYP2C9increases activityEXP 6480464CTDRifampin results in increased activity of CYP2C9 proteinPMID:14722322 PMID:19497360 PMID:22126990 PMID:22843569 PMID:27590069
CYP2C9increases expressionEXP 6480464CTDRifampin results in increased expression of CYP2C9 mRNA; Rifampin results in increased expression of CYP2C9 proteinPMID:14600250 PMID:14722322 PMID:15629111 PMID:15802389 PMID:15919766 PMID:16267138 PMID:16608920 PMID:17590308 PMID:17954527 PMID:19041297 PMID:19118567 PMID:19202563 PMID:19497360 PMID:19686824 PMID:24259679 PMID:24552687 PMID:24830941 PMID:25929522 PMID:26196221 PMID:27794450 PMID:27917125 PMID:28887089 PMID:34689256
CYP2C9multiple interactionsEXP 6480464CTDKetoconazole inhibits the reaction [Rifampin results in increased expression of CYP2C9 mRNA]; NCOA6 promotes the reaction [Rifampin promotes the reaction [[HNF4A co-treated with NR1I2] results in increased expression of CYP2C9 mRNA]]; NR1I2 protein affects the reaction [Rifampin results in increased expression of CYP2C9 mRNA]; Rifampin promotes the reaction [[HNF4A co-treated with NCOA6] results in increased expression of CYP2C9 mRNA]; Rifampin promotes the reaction [[HNF4A co-treated with NR1I2] results in increased expression of CYP2C9 mRNA]; Rifampin promotes the reaction [NR1I2 protein results in increased expression of CYP2C9 mRNA]; Rifampin results in increased activity of and results in increased expression of CYP2C9 protein; Rifampin results in increased expression of and results in increased activity of CYP2C9 proteinPMID:14600250 PMID:14709624 PMID:15802389 PMID:16608920 PMID:19202563 PMID:21292004
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