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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11476
Species: Mus musculus
RGD Object: Gene
Symbol: Ugt1a1
Name: UDP glucuronosyltransferase 1 family, polypeptide A1
Acc ID: CHEBI:28077
Term: rifampicin
Definition: A member of the class of rifamycins that is a a semisynthetic antibiotic derived from Amycolatopsis rifamycinica (previously known as Amycolatopsis mediterranei and Streptomyces mediterranei)
Chemical ID: MESH:D012293
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionISORGD:13500186480464CTDRifampin affects the expression of UGT1A1 mRNA

PMID:15849716
increases expressionISORGD:13500186480464CTDRifampin results in increased expression of UGT1A1 mRNA

PMID:15104253, PMID:15771232, PMID:22126990, PMID:24259679, PMID:31233785
multiple interactionsISORGD:13500186480464CTD[Rifampin co-treated with NR1I2 protein] results in increased expression of UGT1A1 mRNA, [Tetrachlorodibenzodioxin co-treated with Rifampin] results in increased expression of UGT1A1 mRNA

PMID:18098064, PMID:29162470
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.