Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735868
Species: Homo sapiens
RGD Object: Gene
Symbol: NQO1
Name: NAD(P)H quinone dehydrogenase 1
Acc ID: CHEBI:28073
Term: chromium atom
Definition: A chromium group element atom that has atomic number 24.
Chemical ID: MESH:D002857
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases degradationISORGD:104736480464CTDChromium results in increased degradation of NQO1 mRNA

PMID:18474416
increases expressionISORGD:104736480464CTDChromium results in increased expression of NQO1 mRNA

PMID:18474416
multiple interactionsISORGD:104736480464CTD[Azacitidine co-treated with Butyrates] inhibits the reaction [Chromium inhibits the reaction [Benzo(a)pyrene results in increased expression of NQO1 mRNA]], Azacitidine inhibits the reaction [Chromium inhibits the reaction [Benzo(a)pyrene results in increased expression of NQO1 mRNA]], Butyrates inhibits the reaction [Chromium inhibits the reaction [Benzo(a)pyrene results in increased expression of NQO1 mRNA]], Chromium inhibits the reaction [Benzo(a)pyrene results in increased activity of NQO1 protein], Chromium inhibits the reaction [Benzo(a)pyrene results in increased expression of NQO1 mRNA], Chromium inhibits the reaction [beta-Naphthoflavone results in increased activity of NQO1 protein], Chromium inhibits the reaction [beta-Naphthoflavone results in increased expression of NQO1 mRNA], Chromium inhibits the reaction [Methylcholanthrene results in increased activity of NQO1 protein], Chromium inhibits the reaction [Methylcholanthrene results in increased expression of NQO1 mRNA], Chromium inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of NQO1 protein], Chromium inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of NQO1 mRNA], Chromium promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of NQO1 mRNA], Cycloheximide promotes the reaction [Chromium results in increased expression of NQO1 mRNA], Dactinomycin promotes the reaction [Chromium inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of NQO1 mRNA]]

PMID:10972992, PMID:15337587, PMID:17682057, PMID:18474416
multiple interactionsISORGD:25036480464CTD[Dicumarol results in decreased activity of NQO1 protein] which results in decreased reduction of Chromium

PMID:1379126
Go Back to source page   Continue to Ontology report

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.