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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736485
Species: Mus musculus
RGD Object: Gene
Symbol: Sqstm1
Name: sequestosome 1
Acc ID: CHEBI:28061
Term: alpha-D-galactose
Definition: D-Galactopyranose having alpha-configuration at the anomeric centre.
Chemical ID: MESH:D005690
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sqstm1increases expressionEXP 6480464CTDGalactose results in increased expression of SQSTM1 proteinPMID:36792013
Sqstm1multiple interactionsEXP 6480464CTD(1E,4E)-1,5-bis(2-methoxyphenyl)penta-1,4-dien-3-one inhibits the reaction [Galactose results in increased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [(1E,4E)-1,5-bis(2-methoxyphenyl)penta-1,4-dien-3-one inhibits the reaction [Galactose results in increased expression of SQSTM1 protein]]PMID:36792013
Sqstm1increases expressionISOSqstm1 (Rattus norvegicus)6480464CTDGalactose results in increased expression of SQSTM1 proteinPMID:28302704
Sqstm1increases expressionISOSQSTM1 (Homo sapiens)6480464CTDGalactose results in increased expression of SQSTM1 proteinPMID:28302704 PMID:29426000
Sqstm1multiple interactionsISOSQSTM1 (Homo sapiens)6480464CTDHydroxychloroquine inhibits the reaction [Metformin inhibits the reaction [Galactose results in increased expression of SQSTM1 protein]]; Metformin inhibits the reaction [Galactose results in increased expression of SQSTM1 protein]; MIR34A mRNA promotes the reaction [Galactose results in increased expression of SQSTM1 protein]PMID:28302704 PMID:29426000
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