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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2366
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcc2
Name: ATP binding cassette subfamily C member 2
Acc ID: CHEBI:28001
Term: vancomycin
Definition: A complex glycopeptide from Streptomyces orientalis. It inhibits a specific step in the synthesis of the peptidoglycan layer in the Gram-positive bacteria Staphylococcus aureus and Clostridium difficile.
Chemical ID: MESH:D014640
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcc2decreases expressionEXP 6480464CTDVancomycin results in decreased expression of ABCC2 mRNA; Vancomycin results in decreased expression of ABCC2 proteinPMID:29964132
Abcc2multiple interactionsEXP 6480464CTDJBP 485 inhibits the reaction [Vancomycin results in decreased expression of ABCC2 mRNA]; JBP 485 inhibits the reaction [Vancomycin results in decreased expression of ABCC2 protein]PMID:29964132
Abcc2multiple interactionsISOAbcc2 (Mus musculus)6480464CTD[Sodium Selenite results in increased abundance of Selenium] inhibits the reaction [[Vancomycin co-treated with Neomycin co-treated with Ampicillin co-treated with Metronidazole co-treated with Amphotericin B] results in increased expression of ABCC2 mRNA]; [Vancomycin co-treated with Imipenem] affects the expression of ABCC2 mRNA; [Vancomycin co-treated with Neomycin co-treated with Ampicillin co-treated with Metronidazole co-treated with Amphotericin B] results in increased expression of ABCC2 mRNAPMID:24657338 PMID:36464106
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