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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736792
Species: Homo sapiens
RGD Object: Gene
Symbol: ADCYAP1R1
Name: ADCYAP receptor type I
Acc ID: CHEBI:27958
Term: cocaine
Definition: A tropane alkaloid obtained from leaves of the South American shrub Erythroxylon coca.
Chemical ID: MESH:D003042
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ADCYAP1R1increases expressionISOAdcyap1r1 (Mus musculus)6480464CTDCocaine results in increased expression of ADCYAP1R1 mRNAPMID:29673861
ADCYAP1R1multiple interactionsISOAdcyap1r1 (Mus musculus)6480464CTDalpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide affects the reaction [IL6 protein affects the reaction [Cocaine results in increased expression of ADCYAP1R1 mRNA]]; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Cocaine results in increased expression of ADCYAP1R1 mRNA]; IL6 protein affects the reaction [Cocaine results in increased expression of ADCYAP1R1 mRNA]; TNF protein affects the reaction [Cocaine results in increased expression of ADCYAP1R1 mRNA]PMID:29673861
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