Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736778
Species: Mus musculus
RGD Object: Gene
Symbol: Grm5
Name: glutamate receptor, metabotropic 5
Acc ID: CHEBI:27958
Term: cocaine
Definition: A tropane alkaloid obtained from leaves of the South American shrub Erythroxylon coca.
Chemical ID: MESH:D003042
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Grm5affects expressionEXP 6480464CTDCocaine affects the expression of GRM5 mRNAPMID:9886066
Grm5affects localizationEXP 6480464CTDCocaine affects the localization of GRM5 proteinPMID:15295029
Grm5decreases response to substanceEXP 6480464CTDGRM5 mutant form results in decreased susceptibility to CocainePMID:20826661
Grm5increases expressionEXP 6480464CTDCocaine deficiency results in increased expression of GRM5 mRNAPMID:27126842
Grm5affects expressionISOGrm5 (Rattus norvegicus)6480464CTDCocaine affects the expression of GRM5 proteinPMID:19105975 PMID:19118598 PMID:20534846
Grm5increases expressionISOGrm5 (Rattus norvegicus)6480464CTDCocaine results in increased expression of GRM5 mRNAPMID:17898221 PMID:24810662
Grm5multiple interactionsISOGrm5 (Rattus norvegicus)6480464CTDCocaine results in decreased expression of and results in decreased activity of GRM5 proteinPMID:20416862
Go Back to source page   Continue to Ontology report