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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736752
Species: Homo sapiens
RGD Object: Gene
Symbol: CAMK2A
Name: calcium/calmodulin dependent protein kinase II alpha
Acc ID: CHEBI:27958
Term: cocaine
Definition: A tropane alkaloid obtained from leaves of the South American shrub Erythroxylon coca.
Chemical ID: MESH:D003042
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CAMK2Aaffects response to substanceISOCamk2a (Mus musculus)6480464CTDCAMK2A affects the susceptibility to CocainePMID:14725635
CAMK2Aincreases expressionISOCamk2a (Rattus norvegicus)6480464CTDCocaine results in increased expression of CAMK2A proteinPMID:14725635
CAMK2Amultiple interactionsISOCamk2a (Mus musculus)6480464CTDCocaine results in increased expression of and results in increased phosphorylation of CAMK2A protein; Nifedipine inhibits the reaction [Cocaine results in increased expression of and results in increased phosphorylation of CAMK2A protein]PMID:28194001
CAMK2Amultiple interactionsISOCamk2a (Rattus norvegicus)6480464CTD7-chlorokynurenic acid inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of CAMK2A protein]; Cocaine promotes the reaction [DRD3 protein binds to CAMK2A protein]; Cocaine results in increased phosphorylation of and results in increased activity of CAMK2A protein; KN 93 inhibits the reaction [Cocaine promotes the reaction [DRD3 protein binds to CAMK2A protein]]; Sodium Benzoate promotes the reaction [Cocaine results in increased phosphorylation of and results in increased activity of CAMK2A protein]PMID:17609678 PMID:19217379
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