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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 734156
Species: Mus musculus
RGD Object: Gene
Symbol: Smad1
Name: SMAD family member 1
Acc ID: CHEBI:27958
Term: cocaine
Definition: A tropane alkaloid obtained from leaves of the South American shrub Erythroxylon coca.
Chemical ID: MESH:D003042
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Smad1multiple interactionsISOSmad1 (Rattus norvegicus)6480464CTD[Cocaine co-treated with Cocaine deficiency] inhibits the reaction [SMURF1 protein binds to SMAD1 protein modified form]; [Cocaine co-treated with Cocaine deficiency] results in decreased ubiquitination of SMAD1 protein modified form; [Cocaine co-treated with Cocaine deficiency] results in increased expression of and results in increased phosphorylation of SMAD1 proteinPMID:30158054
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