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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3731
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sod1
Name: superoxide dismutase 1
Acc ID: CHEBI:27958
Term: cocaine
Definition: A tropane alkaloid obtained from leaves of the South American shrub Erythroxylon coca.
Chemical ID: MESH:D003042
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sod1decreases expressionISOSOD1 (Homo sapiens)6480464CTDCocaine results in decreased expression of SOD1 mRNAPMID:12629581
Sod1increases activityISOSod1 (Mus musculus)6480464CTDCocaine results in increased activity of SOD1 proteinPMID:30027653
Sod1multiple interactionsISOSod1 (Mus musculus)6480464CTDGPX1 affects the reaction [Cocaine results in increased activity of SOD1 protein]PMID:30027653
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