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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3233
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Oprd1
Name: opioid receptor, delta 1
Acc ID: CHEBI:27958
Term: cocaine
Definition: A tropane alkaloid obtained from leaves of the South American shrub Erythroxylon coca.
Chemical ID: MESH:D003042
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Oprd1affects localizationEXP 6480464CTDCocaine affects the localization of OPRD1 proteinPMID:18417105
Oprd1multiple interactionsEXP 6480464CTD[Enkephalin, D-Penicillamine (2,5)- binds to and results in increased activity of OPRD1 protein] which results in increased susceptibility to Cocaine; naltrindole inhibits the reaction [[Enkephalin, D-Penicillamine (2,5)- binds to and results in increased activity of OPRD1 protein] which results in increased susceptibility to Cocaine]PMID:19279569
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